Description
Product Characteristics:
Aliases: 183ActI antibody, CD158 antigen like family member J antibody, CD158b antibody, CD158J antibody, CD158j antigen antibody, cl 49 antibody, KI2S2_HUMAN antibody, killer cell Ig like receptor antibody, Killer cell immunoglobulin-like receptor 2DS2 antibody, Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 antibody, KIR2DS2 antibody, MHC class I NK cell receptor antibody, Natural killer associated transcript 5 antibody, natural killer cell inhibitory receptor antibody, NK receptor 183 Actl antibody, NKAT 5 antibody, NKAT5 antibody, p58 killer cell inhibitory receptor KIR K7a antibody, p58 KIR antibody, p58 natural killer cell receptor clone CL 49 antibody, p58 NK receptor CL 49 antibody
Target Information: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\, thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]